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What is PrEP?

PrEP (short for Pre-Exposure Prophylaxis) is medication that prevents HIV and promotes sexual health.

PrEP is for anyone – straight, gay or bisexual. PrEP is for male, female, transgender or gender non-conforming individuals.

PrEP is for people who are HIV negative (not living with HIV). When a person takes PrEP as directed, it is 99% effective at preventing HIV.

There are two medications approved by the FDA as PrEP for HIV: Truvada and Descovy. A health care provider will work with you to determine which may be best for you.

Is it safe?

Yes. PrEP is very safe. Most people have few or no side effects. Some people get an upset stomach when they first start taking it. Talk to your health care provider about any side effects, especially if they last more than a week or so.

How do I get PrEP?

PrEP is individualized to support your sexual health and HIV prevention needs. You will need a prescription from a health care provider to get PrEP. You can talk with your healthcare provider about PrEP or you can find a provider by clicking here.

How much does PrEP cost?

Everyone interested in PrEP will be able to afford it because there are many options for covering the costs. The cost of PrEP includes the cost of medication, medical appointments, and lab tests. Medicaid and most health insurance plans cover all the costs for PrEP, without co-pays or cost-sharing. Drug manufacturers offer assistance and the New York State DOH offers a PrEP Assistance Program (PrEP-AP). For information, see PrEP Payment Options (PDF).

How often do I take PrEP?

Daily PrEP

Taking PrEP once a day is the preferred method. Talk with your healthcare provider about how long you need to take PrEP before you are fully protected. Daily PrEP with Truvada is the only method proven to be effective for cis-gender women and transgender men who have vaginal intercourse.

On-Demand PrEP (2-1-1)

On-demand PrEP is an option for you if you are a cisgender man who has sex with men and you can predict when you will have sex at least 2 hours beforehand. With on-demand PrEP, you take two pills, at least 2-24 hours before sex. Then you take one pill, once a day for two days after you have had sex. The only PrEP medication approved for on-demand use is Truvada.

If you feel you no longer need PrEP, talk with your health care provider about how to discontinue it.

PrEP and HIV Testing

PrEP is for people who are HIV negative, so the first step is an HIV test. While you are taking PrEP, you should get tested for HIV periodically to make sure you remain HIV negative.

PrEP, Condoms and STIs

PrEP does not protect you from sexually transmitted infections (STIs) like syphilis, gonorrhea or chlamydia. Using a male or female condom with PrEP will protect you from most STIs. When you are taking PrEP, you should get tested periodically for STIs. Early diagnosis and treatment of STIs protects your health and prevents passing STIs to your partners. Using PrEP and condoms together gives you protection from both HIV and most STIs.


U=U stands for Undetectable equals Untransmittable. It means that a person who has HIV and is on treatment and virally suppressed for 6 months or longer cannot transmit HIV to a partner through sex. To learn more:

If your partner is living with HIV and their HIV is virally suppressed (or undetectable), there is no risk of you getting HIV from sex with this partner.


For more specific information for women, click here PrEP for Women

Campaign Resources

To access campaign resources including videos and still images, click here: Prep Campaign Resources